Antibody-mediated protection against MERS-CoV in the murine model☆
Identifieur interne : 000694 ( Main/Exploration ); précédent : 000693; suivant : 000695Antibody-mediated protection against MERS-CoV in the murine model☆
Auteurs : R. R. C. New [Royaume-Uni] ; B. D. Moore [Royaume-Uni] ; W. Butcher [Royaume-Uni] ; R. Mahood [Royaume-Uni] ; M. S. Lever [Royaume-Uni] ; S. Smither [Royaume-Uni] ; L. O'Brien [Royaume-Uni] ; S. A. Weller [Royaume-Uni] ; M. Bayliss [Royaume-Uni] ; L. C. D. Gibson [Royaume-Uni] ; C. Macleod [Royaume-Uni] ; M. Bogus [Royaume-Uni] ; R. Harvey [Royaume-Uni] ; N. Almond [Royaume-Uni] ; E. D. Williamson [Royaume-Uni]Source :
- Vaccine [ 0264-410X ] ; 2019.
Abstract
A novel dual route vaccination using the MERS-CoV RBD sub-unit has been developed. Murine antisera induced to the RBD protein , were neutralising MERS-CoV susceptibility was induced in naïve mice with Ad5hDPP4. Passive transfer of anti-RBD sera protected susceptible mice. Protected mice had a significantly reduced viral titre (P = 0.02) in their lungs.
Url:
DOI: 10.1016/j.vaccine.2019.05.074
PubMed: 31178378
PubMed Central: 7115393
Affiliations:
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R. C." last="New">R. R. C. New</name><affiliation wicri:level="3"><nlm:aff id="af015">Vaxcine (UK) Ltd, c/o London Bioscience Innovation Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Vaxcine (UK) Ltd, c/o London Bioscience Innovation Centre, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="af030">Faculty of Science and Technology, Middlesex University, The Burroughs, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Science and Technology, Middlesex University, The Burroughs, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Moore, B D" sort="Moore, B D" uniqKey="Moore B" first="B. D." last="Moore">B. D. Moore</name><affiliation wicri:level="1"><nlm:aff id="af010">Pure & Applied Chemistry, University of Strathclyde, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Pure & Applied Chemistry, University of Strathclyde, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Butcher, W" sort="Butcher, W" uniqKey="Butcher W" first="W." last="Butcher">W. Butcher</name><affiliation wicri:level="1"><nlm:aff id="af005">Defence Science & Technology Laboratory, Porton Down, Salisbury, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Defence Science & Technology Laboratory, Porton Down, Salisbury</wicri:regionArea><wicri:noRegion>Salisbury</wicri:noRegion></affiliation></author><author><name sortKey="Mahood, R" sort="Mahood, R" uniqKey="Mahood R" first="R." last="Mahood">R. Mahood</name><affiliation wicri:level="1"><nlm:aff id="af005">Defence Science & Technology Laboratory, Porton Down, Salisbury, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Defence Science & Technology Laboratory, Porton Down, Salisbury</wicri:regionArea><wicri:noRegion>Salisbury</wicri:noRegion></affiliation></author><author><name sortKey="Lever, M S" sort="Lever, M S" uniqKey="Lever M" first="M. S." last="Lever">M. S. Lever</name><affiliation wicri:level="1"><nlm:aff id="af005">Defence Science & Technology Laboratory, Porton Down, Salisbury, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Defence Science & Technology Laboratory, Porton Down, Salisbury</wicri:regionArea><wicri:noRegion>Salisbury</wicri:noRegion></affiliation></author><author><name sortKey="Smither, S" sort="Smither, S" uniqKey="Smither S" first="S." last="Smither">S. Smither</name><affiliation wicri:level="1"><nlm:aff id="af005">Defence Science & Technology Laboratory, Porton Down, Salisbury, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Defence Science & Technology Laboratory, Porton Down, Salisbury</wicri:regionArea><wicri:noRegion>Salisbury</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, L" sort="O Brien, L" uniqKey="O Brien L" first="L." last="O'Brien">L. O'Brien</name><affiliation wicri:level="1"><nlm:aff id="af005">Defence Science & Technology Laboratory, Porton Down, Salisbury, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Defence Science & Technology Laboratory, Porton Down, Salisbury</wicri:regionArea><wicri:noRegion>Salisbury</wicri:noRegion></affiliation></author><author><name sortKey="Weller, S A" sort="Weller, S A" uniqKey="Weller S" first="S. A." last="Weller">S. A. Weller</name><affiliation wicri:level="1"><nlm:aff id="af005">Defence Science & Technology Laboratory, Porton Down, Salisbury, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Defence Science & Technology Laboratory, Porton Down, Salisbury</wicri:regionArea><wicri:noRegion>Salisbury</wicri:noRegion></affiliation></author><author><name sortKey="Bayliss, M" sort="Bayliss, M" uniqKey="Bayliss M" first="M." last="Bayliss">M. Bayliss</name><affiliation wicri:level="1"><nlm:aff id="af005">Defence Science & Technology Laboratory, Porton Down, Salisbury, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Defence Science & Technology Laboratory, Porton Down, Salisbury</wicri:regionArea><wicri:noRegion>Salisbury</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, L C D" sort="Gibson, L C D" uniqKey="Gibson L" first="L. C. D." last="Gibson">L. C. D. Gibson</name><affiliation wicri:level="1"><nlm:aff id="af020">Scottish Biomedical Drug Discovery, West of Scotland Science Park, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Scottish Biomedical Drug Discovery, West of Scotland Science Park, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Macleod, C" sort="Macleod, C" uniqKey="Macleod C" first="C." last="Macleod">C. Macleod</name><affiliation wicri:level="1"><nlm:aff id="af010">Pure & Applied Chemistry, University of Strathclyde, Glasgow, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Pure & Applied Chemistry, University of Strathclyde, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Bogus, M" sort="Bogus, M" uniqKey="Bogus M" first="M." last="Bogus">M. Bogus</name><affiliation wicri:level="3"><nlm:aff id="af015">Vaxcine (UK) Ltd, c/o London Bioscience Innovation Centre, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Vaxcine (UK) Ltd, c/o London Bioscience Innovation Centre, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Harvey, R" sort="Harvey, R" uniqKey="Harvey R" first="R." last="Harvey">R. Harvey</name><affiliation wicri:level="1"><nlm:aff id="af025">National Institute for Biological Standards and Control, Potters Bar, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Biological Standards and Control, Potters Bar</wicri:regionArea><wicri:noRegion>Potters Bar</wicri:noRegion></affiliation></author><author><name sortKey="Almond, N" sort="Almond, N" uniqKey="Almond N" first="N." last="Almond">N. Almond</name><affiliation wicri:level="1"><nlm:aff id="af025">National Institute for Biological Standards and Control, Potters Bar, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Biological Standards and Control, Potters Bar</wicri:regionArea><wicri:noRegion>Potters Bar</wicri:noRegion></affiliation></author><author><name sortKey="Williamson, E D" sort="Williamson, E D" uniqKey="Williamson E" first="E. D." last="Williamson">E. D. Williamson</name><affiliation wicri:level="1"><nlm:aff id="af005">Defence Science & Technology Laboratory, Porton Down, Salisbury, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Defence Science & Technology Laboratory, Porton Down, Salisbury</wicri:regionArea><wicri:noRegion>Salisbury</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">A novel dual route vaccination using the MERS-CoV RBD sub-unit has been developed.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">Murine antisera induced to the RBD protein , were neutralising <italic>in vitro</italic>.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">MERS-CoV susceptibility was induced in naïve mice with Ad5hDPP4.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">Passive transfer of anti-RBD sera protected susceptible mice.</p></list-item><list-item id="o0025"><label>•</label><p id="p0025">Protected mice had a significantly reduced viral titre (P = 0.02) in their lungs.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. 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Moore</name><name sortKey="New, R R C" sort="New, R R C" uniqKey="New R" first="R. R. C." last="New">R. R. C. New</name><name sortKey="O Brien, L" sort="O Brien, L" uniqKey="O Brien L" first="L." last="O'Brien">L. O'Brien</name><name sortKey="Smither, S" sort="Smither, S" uniqKey="Smither S" first="S." last="Smither">S. Smither</name><name sortKey="Weller, S A" sort="Weller, S A" uniqKey="Weller S" first="S. A." last="Weller">S. A. Weller</name><name sortKey="Williamson, E D" sort="Williamson, E D" uniqKey="Williamson E" first="E. D." last="Williamson">E. D. Williamson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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